Ajay' CV

Academic Qualifications:

2006- : Persuing Post-Graduate Diploma in Business Administration

(Finance) from Symbiosis Centre for Distance Learning, Pune.

1997-2002: Ph.D., University of Delhi, Delhi, India.

Title of Ph.D. Thesis: Smart Hydrogel Polymeric Micelle Nanoparticles as Carriers for Ocular Delivery.

1995-1997: M.Sc (Physical Chemistry), 1997, University of Delhi, Delhi, India.

1992-1995: B.Sc (Hons.) Chemistry, 1995, University of Delhi, Delhi, India.

PROFESSIONAL EXPERIENCE:

March, 06 - Present: Group Leader, Formulation Development - NDDS at Torrent Pharmaceutical Ltd., Ahmedabad, India.

May, 2005 - March, 2006: Assistant Manager-R&D, Pharma. Research at Panacea Biotec Ltd., New Link Road, Chakala, Andheri (E), Mumbai, India.

Nov., 2003– Jan, 2005: Research Scientist at Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow, U.K.

Jan., 2002 – Oct., 2003: Post Doctoral Research Assistant at Centre for Cell Engineering, University of Glasgow, Glasgow, Scotland, U.K.

July, 2001- Dec., 2001: Research Scholar after PhD thesis submission at Department of Chemistry, University of Delhi, Delhi, India.

July, 2000- Dec., 2000: Visiting Research Fellow in All India Institute of Biomedical Sciences (AIIMS), New Delhi, India.

June, 1997- September, 1997: Teacher at Harewali Sanskrit Vidhyapeetha, Affiliated to Rashtriya Sanskrit Sansthan, Delhi, India.

Patents:

(1) Amarnath Maitra, Ajay Kumar Gupta, Dipak Majumdar, Sumit Madan; Sustained release and long residing ophthalmic formulation and the process of preparing the same.

United States Patent No.: 6,579519 dated 17^th June, 2003.

(2) Amarnath Maitra, Ajay Kumar Gupta, Dipak Majumdar, Sumit Madan; Sustained release ophthalmic formulations comprising a micelle solution of a random block copolymer and a hydrophobic drug.

Great Britain Patent No.: GB200122506 dated 29^th May, 2002.

(3) Amarnath Maitra, Ajay Kumar Gupta, Dipak Majumdar, Sumit Madan; Ophtalmologische Formulierung mit verlangsamter freisetzung und langer verweildauer sowie herstellungsverfahren hierfur.

German Patent No.: DE10145910

(4) Amarnath Maitra, Ajay Kumar Gupta, Dipak Majumdar and Sumit Madan, A Process for Preparing Sustained Release and Long Residing Ophthalmic Formulation.

Indian Patent Application No.: 845/Del/2000 Dated 25^th September, 2000.

(5) Amarnath Maitra, Ajay Kumar Gupta, Dipak Majumdar and Sumit Madan, A Sustained Release and Long Residing Ophthalmic Formulation.

Indian Patent Application No.: 871/Del/2000 Dated 26^th September, 2000.

The above technology was transferred to a pharmaceutical company, Panacea Biotech, New Delhi, India.

(6) Ajay Kumar Gupta, Sarabjit Singh and Amarjit Singh, Novel improved compositions for cancer therapy (Patents filed in many countries by Panacea Biotec Ltd.), 2005 - 2006.

Publications:

(1) Ajay Kumar Gupta, Sumit Madan, D.K. Majumdar and Amarnath Maitra, (2000), Ketorolac entrapped in polymeric micelles: Preparation, Characterization and ocular anti-inflammatory studies. International Journal of Pharmaceutics 209(1-2), 1-14.

(2) Ajay Kumar Gupta, Sumit Madan, D.K. Majumdar and Amarnath Maitra; (2000) Ketorolac entrapped in polymeric micelles: Preparation, Characterization and ocular anti-inflammatory studies. Proceed. Int’l Symp. Contol. Rel. Bioact. Mater. 27, #7214, 810-811.

(3)Ajay K. Gupta and A. Curtis, (2002); Surface modification of superpapramagnetic iron oxide nanoparticles and their intracellular uptake; European Cells and Materials, Vol. 4. Suppl. 2, 101-102.

(4) Ajay Kumar Gupta and Adam Curtis; (2003), Lactoferrin and Ceruloplasmin Derivatized Superparamagnetic Iron Oxide Nanoparticles: Preparation, Characterization and Their Influence on Human Dermal Fibroblasts in Culture. Proceed. Int’l Symp. Contol. Rel. Bioact. Mater., 30, # 788.

(5)Mona Gupta and Ajay Kumar Gupta; (2003), Preparation and Characterization of Gelatin Nanoparticles and Their Interactions with Human Dermal Fibroblasts in vitro. Proceed. Int’l Symp. Contol. Rel. Bioact. Mater., 30, # 250.

(6) Ajay Kumar Gupta and Mona Gupta; (2003), In vitro Cytotoxicity Studies of Hydrogel Pullulan Nanoparticles Prepared By Water-in-Oil Microemulsions. Proceed. Int’l Symp. Contol. Rel. Bioact. Mater., 30, # 354.

(7)Ajay Kumar Gupta and Adam S.G. Curtis, (2003); Receptor Mediated Targeting of Magnetic Nanoparticles Using Insulin as a Surface Ligand to Prevent Endocytosis. IEEE Transactions on NanoBioscience, 2(4), 255-261.

(8)A. K. Gupta, M. Gupta & A. N. Maitra, (2003); Polymeric Nanoparticles Encapsulating NSAIDs for Ocular Delivery: Corneal Penetration and Polymorphonuclear Leukocyte Migration Studies; European Cells and Materials, Vol. 6. Suppl. 2, 40.

(9)Mona Gupta, Ajay K. Gupta, A.S.G. Curtis & S. Yarwood, (2003), Preparation and in vitro Evaluation of Pullulan Nanoparticles as Gene Transfection System, European Cells and Materials, Vol. 6. Suppl. 2, 39.

(10)Ajay Kumar Gupta and Stephen Wells, (2004); Surface Modified Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery: Preparation, Characterization and Cytotoxicity Studies. IEEE Transactions on NanoBioscience, 3(1), 66-73.

(11)Ajay Kumar Gupta and Adam S.G. Curtis, (2004); Lactoferrin and Ceruloplasmin Derivatized Superparamagnetic Iron Oxide Nanoparticles For Targeting Cell Surface Receptors, Biomaterials, 25(15), 3029-3040.

(12) Ajay Kumar Gupta, Mona Gupta, Stephen J. Yarwood, Adam S.G. Curtis; (2004); Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts, Journal of Controlled Release, 95(2), 197-207.

(13) Mona Gupta and Ajay Kumar Gupta, (2004); In vitro Cytotoxicity Studies of Hydrogel Pullulan Nanoparticles Prepared in Water-in-Oil Microemulsion, Journal of Pharmacy & Pharmaceutical Sciences, 7(1), 38-46.

(14) Ajay Kumar Gupta and Adam S.G. Curtis, (2004); Surface Modified Superpara- magnetic Iron Oxide Nanoparticles For Drug Delivery: Interaction Studies with human fibroblasts in Culture, Journal of Material Science: Materials in Medicine, 15(4), 493-496.

(15) Hydrogel pullulan nanoparticles encapsulating pBUDLacZ plasmid as an efficient gene delivery carrier, Journal of Controlled Release,99(1),157-166 (2004)

(16) Ajay Kumar Gupta and Mona Gupta, (2005); Cytotoxicity Suppression and Cellular Uptake Enhancement of Surface Modified Magnetic Nanoparticles, Biomaterials, 26(13), 1565-1573.

(17) Ajay Kumar Gupta and Mona Gupta, (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications, Biomaterials, 26(18), 3995-4021.

(18) Ajay Kumar Gupta, Mona Gupta and Amarnath Maitra, (2004), Copolymeric Micelles encapsulating indomethacin and nimesulide as potential ocular carriers (Submitted to European Journal of Pharmaceutical Sciences).

(19) Ajay Kumar Gupta, Mona Gupta and Amarnath Maitra, (2004), Pilocarpine prodrug encapsulated in copolymeric Micelles for improved glaucoma therapy. (Submitted to Journal of Controlled Release).

(20) Mona S. Gupta, Ajay Kumar Gupta and Amarnath Maitra, (2004), Modulation of Intestinal Uptake of Copolymeric Micelles Nanoparticles By Optimizing Their Surface Hydrophobicity And Mucoadhesiveness. (Submitted to Journal of Controlled Release)

(21) Ajay Kumar Gupta and Mona Gupta, (2004), Microscopic characterization of surface functionalized magnetic nanoparticles for biomedical applications. (Invited review article for Micron)

(22) Ajay Kumar Gupta, Mona Gupta and Amarnath Maitra, (2004), Evaluation of smart copolymeric nanomicelles for ocular delivery (Under preparation)

Chapters in Books:

(1) A.K. Gupta, S. Madan, D.K. Majumder and A.N. Maitra; Ketorolac entrapped in polymeric micelles: Preparation, Characterization and ocular anti-inflammatory studies. (2000), In: Newer Drugs in Ophthalmology; Edited by N.R.Biswas and S.K.Jain; Published by Pragati Publishing Co., India; pp: 1-4.

(2) N.R. Biswas, J.S. Tityal, G.K. Das, A. Gupta, A.K. Gupta and A.N. Maitra; In vivo Efficacy and Toxicity Studies in Animals of Nanoparticulated Ketrolac. (2000), In: Newer Drugs in Ophthalmology; Edited by N.R.Biswas and S.K.Jain; Published by Pragati Publishing Co., India; pp.: 5-7.

(3) G.K. Das, S.K. Khokhar, N.R. Biswas, N. Kumar, A. Gupta, A.K. Gupta and A.N. Maitra; Comparative efficacy of ketorolac (plain) and ketrolac (nano-particle carrier form) in post operative cataract patients in a prospective randomized double blind multicentric clinical study. (2000), In: Newer Drugs in Ophthalmology; Edited by N.R.Biswas and S.K.Jain; Published by Pragati Publishing Co., India; pp: 32-34.

(4) N.R. Biswas, S.K. Khokhar, G.K. Das, N. Kumar, A.K. Gupta and A.N. Maitra Nanoparticulated Ketorolac compared with plain ketorolac in acute vernal Kerato-Conjunctivitis- An open, randomized, Multicentric Indian Study. (2000), In: Newer Drugs in Ophthalmology; Edited by N.R.Biswas and S.K.Jain; Published by Pragati Publishing Co., India; pp: 35-37.

Journal Reviewer

(1) Biomaterials

(2) Pharmaceutical Research

HONORS AND AWARDS:

(1) Successfully completed the Young Scientists Referring Programme for the journal ‘Biomaterials’ (April, 2004).

(2) Post-Doctoral Fellowship (2002-2003) from European Commission under the ‘Competitive and Sustainable Growth’ (1998-2002) Program; Magnetic Nanoparticles for Medical and Biological Diagnostics and Devices (MAGNANOMED).

(3) Senior Research Fellowship (2000-2001) and Junior Research Fellowship (1998-2000) from Department of Biotechnology, Govt. of India, sponsored research project entitled "Particulate Carriers for Targeting Mammalian Cell Types Using Nanotechnology."

(4) Graduate Aptitude Test in Engineering (GATE) organized by Indian Institute of Technology (IIT), Delhi, in 1998 with percentile score 89.98.

(5) Joint Council of Scientific and Industrial Research -University Grant Commission (CSIR-UGC) National Eligibility Test (NET) for Lectureship, December,1998.

(6) Travel grant from Council of Scientific and Industrial Research (CSIR), India and Department of Science and technology (DST), India to attend “The 27^th International Symposium on Controlled Release of Bioactive materials.” Organized by Controlled Release Society, Inc. Paris, France, July 7-13, 2000.

Conferences / Symposium Attended:

(1) Ajay Kumar Gupta, Sumit Madan, D.K.Majumdar and Amarnath Maitra; Ocular Anti-inflammatory Effect of Ketorolac Entrapped in Polymeric Micelles, 4^th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, The School of Pharmacy, University of London, London, U.K. 5-7^th January, 2000.

(2) Ajay Kumar Gupta, Sumit Madan, D.K.Majumdar and Amarnath Maitra; Preparation, Characterization and Ocular anti-inflammatory activity studies of Ketorolac Entrapped in Polymeric Micelle Nanoparticles. International Symposium on trends in Medicinal Chemistry and Biocatalysis. Organized by Department of Chemistry, University of Delhi, Delhi, India, 26-29^th January, 2000.

(3) Seminar on "Consultancy opportunities and emerging issues in Biotechnology." Organized by Consultancy Development center and sponsored by Department of Biotechnology, Govt. of India. India Habitat Center, Lodhi Road, New Delhi, India, 12-13^th May, 2000.

(4) Ajay Kumar Gupta, Sumit Madan, D.K.Majumdar and Amarnath Maitra; Ketorolac entrapped in polymeric micelles: Preparation, Characterization and ocular anti-inflammatory studies. The 27^th International Symposium on Controlled Release of Bioactive materials. Organized by Controlled Release Society, Inc. Paris, France, July 7-13, 2000.

(5) Ajay Kumar Gupta, Sumit Madan, D.K.Majumdar and Amarnath Maitra; Non-Steroidal Anti-inflammatory Drugs (NSAIDs) Entrapped in Polymeric Micelles Nanoparticles for Ocular Delivery, Update on New Drug Development on Ocular Pharmacology; Organized by Dr. R.P. Centre, AIIMS, Pharmacy Council of India and Indian Pharmaceutical Association, Delhi, AIIMS, Ansari Nagar, New Delhi, India, 4^th November, 2000, (Invited Speaker).

(6) Ajay K. Gupta and A. Curtis; Surface modification of superparamagnetic iron oxide nanoparticles and their intracellular uptake. Annual meeting of the U.K. Tissue and Cell Engineering Society (TCES), 19-20 September 2002, Glasgow, Scotland.

(7) Ajay Kumar Gupta and Adam Curtis; Lactoferrin and Ceruloplasmin Derivatized Superparamagnetic Iron Oxide Nanoparticles: Preparation, Characterization and Their Influence on Human Dermal Fibroblasts in Culture. The 30^th International Symposium on Controlled Release of Bioactive materials. Organized by Controlled Release Society, Inc. Glasgow, Scotland, July 19-23, 2003.

(8) Mona Gupta and Ajay Kumar Gupta; Preparation and Characterization of Gelatin Nanoparticles and Their Interactions with Human Dermal Fibroblasts in vitro. The 30^th International Symposium on Controlled Release of Bioactive materials. Organized by Controlled Release Society, Inc. Glasgow, Scotland, July 19-23, 2003.

(9) Ajay Kumar Gupta and Mona Gupta; In vitro Cytotoxicity Studies of Hydrogel Pullulan Nanoparticles Prepared By Water-in-Oil Microemulsions. The 30^th International Symposium on Controlled Release of Bioactive materials. Organized by Controlled Release Society, Inc. Glasgow, Scotland, July 19-23, 2003.

(10) Mona Gupta, Ajay K. Gupta, A.S.G. Curtis & S. Yarwood; Preparation and in vitro Evaluation of Pullulan Nanoparticles as Gene Transfection System. Annual meeting of the U.K. Tissue and Cell Engineering Society (TCES), 8-10th September, 2003, Cardiff, Wales, U.K.

(11) Ajay. K. Gupta, M. Gupta & A. N. Maitra; Polymeric Nanoparticles Encapsulating NSAIDs for Ocular Delivery: Corneal Penetration and Polymorphonuclear Leukocyte Migration Studies. Annual meeting of the U.K. Tissue and Cell Engineering Society (TCES), 8-10th September, 2003, Cardiff, Wales, U.K.

(12) Ajay Kumar Gupta and Adam Curtis, Surface Modified Superparamagnetic Nanoparticles For Drug Delivery: Preparation, Characterization And Their Interaction With Human Fibroblasts In Culture. 18th European Conference on Biomaterials, 1st-4^th October, 2003, Stuttgart, Germany (Oral Presentation).

(13) Mona Gupta, Ajay Kumar Gupta and Amarnath Maitra; Modulation of Intestinal Uptake of Hydrogel Nanoparticles by Optimizing Their surface hydrophobicity And Mucoadhesiveness. 18th European Conference on Biomaterials, 1st-4th October, 2003, Stuttgart, Germany.

(14) Ajay Kumar Gupta, Mona Gupta, Superparamagentic Iron Oxide Nanoparticles as magic bullets for targeting cells and tissues. "World Conference on Dosing of Antiinfectives - Dosing the Magic bullets" and the "Ehrlich Symposia", 9-11^th September, 2004, Nurnberg, Germany (Invited Speaker).

Transmission electron microscopy picture of superparamagnetic iron oxide nanoparticles.

TEM pictures of Human fibroblasts incubated with lactoferrin coated superparamagnetic iron oxide nanoparticles showing nano- particles at the cell surface (see arrows).

Site last updated on 23rd Nov, 2007